CJ Prosise was drafted by the Seattle Seahawks in the 2016 NFL Draft. In January 2016, Roc Nation Sports announced that it has signed Prosise to its roster of athletes.
On September 5, 2015, Prosise took over lead back duties for Notre Dame in the game against Texas. At the helms of the eventual 38-3 victory, Prosise ran 20 times for 98 yards. In his first start as running back against Virginia, he rushed for 155 yards with a touchdown. In his following start against Georgia Tech, he rushed for 198 yards and 3 touchdowns, including a 91-yard rushing touchdown, the longest in Notre Dame Stadium history. Prosise finished the season rushing for 1,032 yards on 156 carries (11 touchdowns), and 26 receptions for 308 yards (1 touchdown).
In his second season of full play in 2014, Prosise made 6 starts. He recorded his first career touchdown on a 53-yard touchdown grab from Everett Golson in the season-opening victory over Rice on August 30. He rounded out the season with 29 receptions for 516 yards and 2 touchdowns, and led the Fighting Irish in special teams tackles with 11. Prosise threw down a post-season emphasis with 3 receptions for 34 yards, 75-yards rushing on 3 carries (including a 50-yard touchdown run), and one special teams tackle in the Irish’s 31-28 Music City Bowl victory over No. 22 LSU on December 30, 2014.
After redshirting his 2012 freshman year at Notre Dame, Prosise played in all 13 games as a wide receiver and on special teams in the 2013 season where he tallied 7 receptions for 72 yards, and recorded 4 tackles. Prosise saw his first career reception, a 16-yarder, on September 7 against Michigan, and had a career-best 2 receptions for 25 yards, including a career-long 20-yard grab, in the 29-16 victory over Rutgers in the New Era Pinstripe Bowl.